Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine
نویسندگان
چکیده
منابع مشابه
HBeAg-negative chronic hepatitis B: cost-effectiveness of peginterferon alfa-2a compared to lamivudine in Taiwan.
OBJECTIVE In Taiwan, the carrier rate of hepatitis B surface antigen is 15% to 20%, one of the highest in the world. Among chronic hepatitis B (CHB) patients, hepatitis B e antigen (HBeAg)-negative accounts for approximately 40% to 50% of these patients. A recent study found that peginterferon alfa-2a (40 KD) is more effective than lamivudine in treating HBeAg-negative CHB, but its cost-effecti...
متن کاملPredicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B.
OBJECTIVE In a trial of patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, 24 week post-treatment biochemical and virological response rates with peginterferon alpha-2a with or without lamivudine were significantly higher than with lamivudine alone. The effect of pre-treatment factors on post-treatment responses was investigated. METHODS Multivariate analyses were perfo...
متن کاملLong-term virological outcome in chronic hepatitis B patients with a partial virological response to entecavir
BACKGROUND/AIMS The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV. METHODS Chronic hepatitis B patients trea...
متن کاملlong-term efficacy of treatment with lamivudine in hbeag-negative patients with decompensated cirrhosis due to chronic hepatitis b
background: the prognosis of patients with decompensated cirrhosis due to hepatitis b is very poor. it has been shown that lamivudine can improve liver function and delay the need for liver transplantation in hbeag-positive patients with decompensated cirrhosis. however, information regarding long-term use of lamivudine in hbeag-negative patients with cirrhosis is limited. the primary objective...
متن کاملPredictors of response to pegylated interferon treatment in HBeAg-negative patients with chronic hepatitis B.
INTRODUCTION Although pegylated interferons (pegIFNs) alpha-2a and alpha-2b have been used in chronic hepatitis B (CHB) treatment for many years, there are few studies concerning predictors of sustained virologic response (SVR) to pegIFN therapy. In this study, we aimed to investigate the predictors of response to pegIFN treatment in cases with HBeAg-negative CHB infection. METHODOLOGY Sevent...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2004
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.1840400418